Description

Diacylglycerol Kinase Inhibitor I is a potent and selective small molecule inhibitor of diacylglycerol kinase (DGK) isoforms, particularly DGKα. This compound matters as a critical research tool for investigating lipid signaling pathways, specifically the phosphatidic acid (PA) and diacylglycerol (DAG) second messenger systems involved in cell proliferation, migration, and immune response. Life science researchers and pharmaceutical developers need it for target validation, pathway analysis, and preclinical studies in oncology, immunology, and neurology.

Application

• Biochemical Research: Used as a selective pharmacological tool to inhibit DGK activity in in vitro enzyme assays and cell-based studies.
• Signal Transduction Studies: Essential for elucidating the role of diacylglycerol kinases in regulating protein kinase C (PKC), RasGRP, and other DAG-mediated signaling pathways.
• Cancer Research: Investigated for its effects on cancer cell proliferation, survival, and metastasis by modulating lipid second messengers.
• Immunology Research: Applied in studies of T-cell activation, anergy, and function, where DGK activity is a key regulator.
• Neuroscience Research: Utilized in research exploring synaptic plasticity, neuronal development, and neurological disorders linked to lipid signaling.
• Drug Discovery: Serves as a reference compound and starting point for the development of novel therapeutic agents targeting DGK in various diseases.

Basic Information

Product Name	Diacylglycerol Kinase Inhibitor I
CAS No.	93076-89-2
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	R 59-022; DGK Inhibitor I; 3-{2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl}-5-isoquinolinesulfonamide dihydrochloride; 5-Isoquinolinesulfonamide, 3-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]-, dihydrochloride; R59022; R-59022; Diacylglycerol kinase inhibitor R59022
EINECS	Contact for details

Quality Control

Our Diacylglycerol Kinase Inhibitor I is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure high chemical and biological consistency for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.