Description

10-Deacetyl-13-Oxobaccatin Iii is a key taxane diterpenoid intermediate, recognized for its critical role in the semi-synthesis of potent anticancer agents. This high-purity compound is essential for pharmaceutical research and development, offering a reliable building block for complex molecular synthesis. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on oncology drug development and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the semi-synthetic production of paclitaxel (Taxol®) and related taxane-based chemotherapeutic agents.
• Research & Development: Serves as a reference standard and starting material for medicinal chemistry programs targeting novel microtubule-stabilizing anticancer drugs.
• Biosynthetic Pathway Studies: Used in biochemical research to study and elucidate the taxol biosynthetic pathway in yew plants.
• Fine Chemical Synthesis: Employed in the synthesis of novel taxane derivatives for structure-activity relationship (SAR) studies and new drug discovery.
• Academic Research: Utilized in university and institutional labs for advanced studies in natural product chemistry and organic synthesis methodologies.

Basic Information

Product Name	10-Deacetyl-13-Oxobaccatin Iii
CAS No.	92950-42-0
Molecular Formula	C29H36O10
Molecular Weight	544.59 g/mol
Synonyms	10-Deacetyl-13-oxobaccatin III; 13-Oxo-10-deacetylbaccatin III; 10-Deacetyl-13-oxobaccatin III; 10-Deacetyl-13-oxobaccatin 3; Baccatin derivative; Taxane intermediate; 10-DAB III derivative; 13-Oxo-10-DAB III
EINECS	Contact for details

Quality Control

Our 10-Deacetyl-13-Oxobaccatin Iii is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for pharmaceutical research. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.