Description

2'-Acetyltaxol is a semi-synthetic derivative of the potent anticancer agent Paclitaxel, characterized by an acetyl group at the 2' position of the taxane core structure. This modification is crucial for pharmaceutical research, particularly in structure-activity relationship (SAR) studies aimed at developing novel chemotherapeutic agents with improved efficacy or reduced side effects. It serves as a key intermediate and reference standard for researchers and manufacturers in the oncology drug discovery, process development, and analytical chemistry sectors.

Application

• Pharmaceutical Intermediate: A critical building block in the semi-synthesis and structural modification of Paclitaxel and related taxane derivatives.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate the mechanisms of action, metabolism, and resistance pathways of taxane-based therapies.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemists to understand how modifications to the taxane scaffold affect biological activity and pharmacokinetic properties.
• Process Chemistry: Utilized in the development and optimization of synthetic routes for complex anticancer agents.

Basic Information

Item	Details
Product Name	2'-Acetyltaxol
CAS No.	92950-40-8
Molecular Formula	C47H51NO14
Molecular Weight	853.91 g/mol
Synonyms	2'-Acetylpaclitaxel; 2'-O-Acetylpaclitaxel; NSC 654663; 7,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxy-9-oxo-5β,20-epoxytax-11-en-2-yl benzoate 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Paclitaxel 2'-acetate
EINECS	Contact for details

Quality Control

Our 2'-Acetyltaxol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.