Description

Aphidicolin Glycinate is a chemically modified derivative of the natural tetracyclic diterpenoid aphidicolin, designed to enhance its solubility and biological activity profile. This compound is a potent and specific inhibitor of eukaryotic DNA polymerase α and δ, making it a critical tool for cell cycle research and the study of DNA replication mechanisms. It is primarily utilized by researchers in pharmaceutical development, academic biochemistry, and molecular biology laboratories for investigating cell proliferation, antiviral activity, and as a reference standard.

Application

• Cell Cycle Research: Used to synchronize eukaryotic cells in the early S-phase by inhibiting nuclear DNA replication.
• Antiviral Studies: Investigated for its activity against herpesviruses and poxviruses due to its specific inhibition of viral DNA polymerases.
• Biochemical Research: Serves as a selective inhibitor to differentiate between various DNA polymerase families (A, B, Y) in enzymatic assays.
• Cancer Research: Employed in studies exploring DNA replication stress, checkpoint activation, and the mechanisms of chemotherapeutic agents.
• Reference Standard: Used in analytical laboratories for quality control and method development via HPLC or LC-MS.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate or precursor for developing more potent antiviral or antiproliferative drug candidates.

Basic Information

Product Name	Aphidicolin Glycinate
CAS No.	92803-82-2
Molecular Formula	C₂₇H₄₁NO₈
Molecular Weight	507.62 g/mol
Synonyms	Aphidicolin glycinate; Aphidicolin 17-glycinate; Aphidicolin Glycine Ester; NSC 330836; Glycine, (17β)-17-[(1R,4aS,5R,6R,8aS)-5,6,8a-trimethyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-1-naphthalenyl]-6-oxo-1,4a-dimethyl-2-oxo-1,4,4a,5,6,7,8,8a-octahydro-2H-naphtho[1,8-bc]furan-5-yl ester; ((17β)-17-((1R,4aS,5R,6R,8aS)-5,6,8a-Trimethyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-1-naphthalenyl)-6-oxo-1,4a-dimethyl-2-oxo-1,4,4a,5,6,7,8,8a-octahydro-2H-naphtho[1,8-bc]furan-5-yl) 2-aminoacetate
EINECS	Contact for details

Quality Control

Our Aphidicolin Glycinate is produced and tested under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.