Description

[3H] Sodium Glycoursodeoxycholate is a tritium-labeled derivative of the bile acid salt sodium glycoursodeoxycholate, making it an essential tool for metabolic and pharmacokinetic research. This radiolabeled compound is critical for high-sensitivity tracer studies, enabling precise tracking of absorption, distribution, and excretion pathways in biological systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on hepatology, gastroenterology, and drug metabolism.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used to investigate the in vivo and in vitro metabolic fate of ursodeoxycholic acid (UDCA) and its conjugates.
• Bile Acid Transport Research: Essential for studying the function and kinetics of hepatic and intestinal bile acid transporters (e.g., NTCP, ASBT).
• Mechanistic Research in Cholestatic Liver Diseases: Enables detailed analysis of bile flow, secretion, and the therapeutic mechanisms of UDCA.
• Biochemical Pathway Analysis: Facilitates the elucidation of enterohepatic circulation and the metabolism of bile acids.
• Development of Analytical Methods: Serves as an internal standard or reference compound in LC-MS/MS and radio-HPLC assays for bile acid quantification.
• Receptor Binding Assays: Employed in studies targeting bile acid receptors such as FXR and TGR5.

Basic Information

Product Name	[3H] Sodium Glycoursodeoxycholate
CAS No.	92411-07-9
Molecular Formula	C26H42NO6Na * (³H)
Molecular Weight	Approx. 487.6 g/mol (unlabeled)
Synonyms	Glycoursodeoxycholic Acid Sodium Salt (³H); Tritiated Sodium Glycoursodeoxycholate; N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine Sodium Salt (³H); 3α,7β-Dihydroxy-5β-cholan-24-oylglycine Sodium Salt (³H); GUDCA-³H Na Salt; Sodium Glyco-³H-ursodeoxycholate; [³H]-GUDC
EINECS	Contact for details

Quality Control

Every batch of [3H] Sodium Glycoursodeoxycholate is manufactured and handled under strict radiochemical purity controls. Quality assurance includes verification of radiochemical purity (typically >97% by radio-HPLC), specific activity, and chemical identity. A comprehensive Certificate of Analysis (CoA) detailing analytical results, including HPLC chromatograms and dose calibration data, is provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. The product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a designated, shielded freezer. Users must follow all local and international regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (e.g., 10-80 Ci/mmol)
Solvent	Ethanol/Water or as specified
Concentration	1 mCi/mL (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.