Description

26-Demethyl-12-Deoxyoligomycin A is a structurally modified derivative of the potent macrolide antibiotic, oligomycin A. This compound is of significant interest in biochemical and pharmacological research due to its specific inhibitory action on mitochondrial ATP synthase (Complex V). It serves as a critical research tool for scientists investigating cellular bioenergetics, ion transport mechanisms, and the development of novel therapeutic agents targeting metabolic pathways.

Application

• Biochemical Research: Used as a specific and potent inhibitor of mitochondrial F1Fo-ATP synthase to study oxidative phosphorylation, cellular respiration, and energy metabolism.
• Pharmacological Studies: Employed in research exploring the role of ATP synthase in disease models, including cancer, neurodegenerative disorders, and ischemia-reperfusion injury.
• Ion Channel Research: Applied in studies investigating the connection between mitochondrial function, proton gradients, and cellular ion homeostasis.
• Antifungal Mechanism Research: Serves as a reference compound for studying the mode of action of oligomycin-class molecules against fungal pathogens.
• Academic & Industrial R&D: A key reagent for universities, research institutes, and pharmaceutical companies engaged in metabolic pathway discovery and drug development.

Basic Information

Product Name	26-Demethyl-12-Deoxyoligomycin A
CAS No.	92308-96-8
Molecular Formula	C44H72O11
Molecular Weight	777.04 g/mol
Synonyms	12-Deoxy-26-demethyloligomycin A; 26-Demethyl-12-deoxy-oligomycin A; Oligomycin A, 26-demethyl-12-deoxy-; 12-Deoxy-26-demethyl-oligomycin A; (3R,4S,5S,8R,9S,10S,11R,13R,15S,17R,18S,19S,20R,21S,23S,24S,25R,27S,29S,31S,33R,35S,37R,39S)-Form I
EINECS	Contact for details

Quality Control

Our 26-Demethyl-12-Deoxyoligomycin A is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, consistency, and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.