Description

Glycerotoxin is a highly potent, naturally derived neurotoxin isolated from the venom of the marine cone snail *Conus geographus*, acting as a selective activator of voltage-gated sodium channels. Its exceptional specificity and nanomolar potency make it an indispensable tool for advanced electrophysiological research, neuronal signaling studies, and mechanistic pharmacology. Researchers in academic neuroscience laboratories, biopharmaceutical R&D centers, and contract research organizations (CROs) rely on high-purity glycerotoxin for precise modulation of neuronal excitability and ion channel characterization. Glycerotoxin CAS NO 92229-20-4 is supplied under stringent quality controls to ensure batch-to-batch reproducibility and functional integrity.

Application

• Electrophysiological studies of voltage-gated Na+ channel subtypes (e.g., Nav1.2, Nav1.6) in primary neurons and heterologous expression systems
• Neurotoxicity screening and mechanism-of-action assessment in preclinical safety pharmacology
• Development and validation of high-content screening assays for ion channel modulators
• Structural biology applications including cryo-EM sample preparation requiring controlled neuronal membrane depolarization
• Investigation of synaptic vesicle release dynamics and neurotransmitter exocytosis pathways
• Reference standard in LC-MS/MS-based quantification methods for marine toxin analysis
• Tool compound for modeling hyperexcitability disorders such as epilepsy and neuropathic pain in vitro
• Quality control reference material for certified reference substance (CRS) producers and metrology labs

Basic Information

Product Name	Glycerotoxin
CAS No.	92229-20-4
Molecular Formula	C37H58N10O10S
Molecular Weight	866.99 g/mol
Synonyms	Glycero-toxin; Glycerotoxin I; Conotoxin GxIA; α-Conotoxin GxIA; α-GxIA; GxIA; Conotoxin GxIA (α-type); [Cys2,Cys8]-α-conotoxin GxIA; α-GxIA (Cys2,Cys8)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (HPLC retention time, mass spectrometry), purity (≥98.5% by HPLC), endotoxin levels (≤0.1 EU/mg), and biological activity via standardized electrophysiological assay on rat DRG neurons. Testing adheres to ISO 17025-accredited protocols and supports compliance with ICH Q5, Q7, and REACH requirements for research-grade bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at −20 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; allow vial to equilibrate to room temperature in a desiccated environment before opening. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	[M+H]+ m/z 867.4 ± 0.5
Assay (HPLC)	≥98.5%
Related Substances	Single impurity ≤0.5%; Total impurities ≤1.5%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Endotoxin	≤0.1 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.