Description

12-o-Tiglylphorbol-13 -Isobutyrate is a highly specific phorbol ester derivative, a class of compounds known for their potent biological activity. This compound is of significant interest in advanced biochemical and pharmacological research due to its role as a protein kinase C (PKC) activator. It is primarily utilized by research institutions and pharmaceutical development laboratories engaged in signal transduction studies, cancer research, and the investigation of inflammatory pathways. The precise molecular structure of this derivative makes it a critical tool for probing specific cellular mechanisms.

Application

• Biochemical Research: As a potent and specific activator of Protein Kinase C (PKC) isoforms for studying intracellular signaling cascades.
• Oncology Studies: Used in cancer research to investigate tumor promotion mechanisms, cell proliferation, and apoptosis.
• Pharmacology & Drug Discovery: Serves as a reference standard and a molecular probe in high-throughput screening for developing PKC-modulating therapeutics.
• Inflammation & Immunology Research: Applied in studies of immune cell activation and the role of PKC in inflammatory responses.
• Neuroscience Research: Utilized to examine PKC's function in neuronal signaling, synaptic plasticity, and neurodegenerative conditions.
• Academic & Institutional R&D: A key reagent for universities and research institutes focusing on cell biology and molecular pharmacology.

Basic Information

Product Name	12-o-Tiglylphorbol-13 -Isobutyrate
CAS No.	92214-54-5
Molecular Formula	C34H48O8
Molecular Weight	584.75 g/mol
Synonyms	12-O-Tiglylphorbol-13-isobutyrate; Phorbol 12-tiglate 13-isobutyrate; TPA derivative; 12-O-(2-Methyl-2-butenoyl)phorbol-13-isobutyrate; NSC 401005; PKC Activator (Tiglyl); 12-Tiglylphorbol-13-isobutyric Acid Ester
EINECS	Contact for details

Quality Control

Our 12-o-Tiglylphorbol-13 -Isobutyrate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and structural confirmation via NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.