Description

Kelatorphan is a potent and selective inhibitor of the enzyme neprilysin (NEP), also known as neutral endopeptidase 24.11. This compound is of significant value in biochemical and pharmacological research for its ability to modulate the degradation of endogenous peptides, including enkephalins and natriuretic peptides. It is primarily utilized by researchers in neuroscience, cardiovascular studies, and drug discovery to investigate pain pathways, memory, and blood pressure regulation.

Application

• Neuroscience Research: Used to study the role of enkephalins and other neuropeptides in pain modulation, addiction, and memory processes by inhibiting their enzymatic breakdown.
• Cardiovascular Research: Employed to investigate the effects of natriuretic peptides on blood pressure and fluid balance through neprilysin inhibition.
• Biochemical Assay Development: Serves as a critical reference standard and tool compound in developing high-throughput screening assays for NEP activity.
• Drug Discovery & Development: Acts as a key pharmacological probe for validating NEP as a therapeutic target in conditions like heart failure, hypertension, and Alzheimer's disease.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in peptidergic signaling pathways.

Basic Information

Product Name	Kelatorphan
CAS No.	92175-57-0
Molecular Formula	C₁₇H₂₄N₂O₅
Molecular Weight	336.38 g/mol
Synonyms	N-[(2R)-2-(Hydroxyaminocarbonylmethyl)-4-methylpentanoyl]-L-alanyl-L-phenylalaninal; (R)-N-(1-Carboxy-4-methylpentyl)alanylphenylalaninal Hydroxamate; Kelatorphan Hydroxamate; Thiorphan Hydroxamate Analog; Neprilysin Inhibitor III; NEP Inhibitor Kelatorphan; Enkephalinase Inhibitor Kelatorphan
EINECS	Contact for details

Quality Control

Our Kelatorphan is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep containers sealed in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.