Description

cis-Tranilast is a specific stereoisomer of the pharmaceutical compound Tranilast, recognized for its potent anti-allergic and anti-fibrotic properties. This high-purity intermediate is critical for research and development in advanced therapeutic areas, particularly in modulating immune responses and tissue remodeling processes. It serves as a key building block for pharmaceutical manufacturers and research institutions focused on developing novel treatments for inflammatory and fibrotic disorders.

Application

• Pharmaceutical Intermediate: Primary use as a high-purity active pharmaceutical ingredient (API) intermediate in the synthesis of advanced therapeutic agents.
• Allergy & Asthma Research: Critical material for R&D into mast cell stabilizers and treatments for allergic conditions like bronchial asthma, allergic rhinitis, and atopic dermatitis.
• Anti-fibrotic Drug Development: Used in preclinical and clinical research targeting keloids, hypertrophic scars, and systemic fibrotic diseases.
• Inflammation Modulation Studies: Employed in biochemical research to study the inhibition of cytokine release (e.g., TGF-β) and inflammatory pathways.
• Reference Standard: Serves as an analytical reference standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for Tranilast and its derivatives under GMP or non-GMP conditions.

Basic Information

Product Name	cis-Tranilast
CAS No.	91920-58-0
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	N-(3,4-Dimethoxycinnamoyl)anthranilic acid (cis-isomer); (Z)-Tranilast; cis-N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; Rizaben (cis-form); Tranilast (Z-isomer); cis-2-[[(3,4-Dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzoic acid; KCA-757; N-5'
EINECS	Contact for details

Quality Control

Our cis-Tranilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with material that can be supplied to meet relevant ICH guidelines and customer-specific monographic requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.