Description

4-Fluorobenzoyl-Carbonyl-13C Chloride is a stable isotope-labeled reagent, specifically featuring a carbon-13 label on the carbonyl carbon. This compound is essential for advanced analytical and synthetic chemistry, providing a distinct isotopic signature for precise tracking and quantification in complex systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical instrumentation sectors who require high-purity, isotopically enriched building blocks for drug metabolism studies, proteomics, and the synthesis of labeled standards.

Application

• Pharmaceutical Research & Development: As a key synthetic intermediate for incorporating a carbon-13 label into target molecules for use in Pharmacokinetic (PK) and Absorption, Distribution, Metabolism, and Excretion (ADME) studies.
• Analytical Reference Standard: Serves as a certified reference material (CRM) or internal standard in quantitative mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy to enhance analytical accuracy and precision.
• Proteomics & Metabolomics: Used in chemical labeling strategies for the isotopic coding of peptides, proteins, or metabolites to enable relative and absolute quantification in complex biological samples.
• Agrochemical Development: Employed in the synthesis of isotopically labeled pesticide or herbicide analogs to study environmental fate, degradation pathways, and residue analysis.
• Medical Diagnostics: Potential use in the development of labeled probes or contrast agents for advanced imaging techniques.
• Organic Synthesis: Acts as a specialized acylating agent for introducing the 4-fluorobenzoyl moiety with a carbon-13 tag into various molecular scaffolds for mechanistic studies.

Basic Information

Product Name	4-Fluorobenzoyl-Carbonyl-13C Chloride
CAS No.	91742-47-1
Molecular Formula	C7H4ClF13CO *
Molecular Weight	~172.56 g/mol *
Synonyms	4-Fluorobenzoyl-13C chloride; 4-Fluorobenzoic-13C acid chloride; p-Fluorobenzoyl-13C chloride; (Carbonyl-13C)-4-fluorobenzoyl chloride; 1-(Chloro(13C)carbonyl)-4-fluorobenzene; 4-Fluorobenzoic-13C anhydride (related); Isotopically labeled 4-fluorobenzoyl chloride
EINECS	Contact for details

* Formula and weight are approximate and based on the 13C isotopic enrichment level. Contact us for exact specifications.

Quality Control

Every batch of our 4-Fluorobenzoyl-Carbonyl-13C Chloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and Mass Spectrometry to confirm isotopic enrichment and positional labeling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and specific tests. Our quality commitment ensures reliability for your most sensitive research and regulatory submission needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Positional Isotopic Purity	≥ 98% on carbonyl carbon

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.