Description

Herbimycin C is a potent benzoquinone ansamycin antibiotic isolated from *Streptomyces hygroscopicus*. This compound is a valuable biochemical tool primarily recognized for its role as a specific inhibitor of Hsp90, a molecular chaperone critical for the stability and function of numerous oncogenic client proteins. It is essential for researchers and developers in life sciences and pharmaceutical discovery who require high-purity, biologically active compounds for target validation, signal transduction studies, and anticancer research.

Application

• Biochemical Research: As a specific Hsp90 inhibitor for studying protein folding, cellular stress response, and chaperone-dependent signaling pathways.
• Oncology Research: Investigation of mechanisms for degrading oncogenic client proteins (e.g., HER2, BCR-ABL, mutant p53) and evaluation of anti-tumor activity in preclinical models.
• Signal Transduction Studies: Tool compound for dissecting the role of Hsp90 in stabilizing various kinases and transcription factors involved in cell proliferation and survival.
• Antibiotic Mechanism Studies: Research into the antimicrobial properties and mode of action of ansamycin-class antibiotics.
• Pharmaceutical Development: A reference standard and lead compound in the discovery and development of novel Hsp90-targeted therapeutics.
• Cell Biology: Used to induce heat shock response and study cellular mechanisms of proteostasis and protein degradation.

Basic Information

Product Name	Herbimycin C
CAS No.	91700-92-4
Molecular Formula	C30H42N2O9
Molecular Weight	574.67 g/mol
Synonyms	Antibiotic Herbimycin C; NSC 329205; 7-O-Carbamoyl-7-deoxygeldanamycin; Benzoquinone Ansamycin Herbimycin C; 5,6-Dihydro-19,21-dihydroxy-3,9,23-trimethoxy-2,4,17,27-tetramethyl-8,28-dioxa-1-azacyclooctacosa-5,10,12,14,16,18,20,25-octaene-7,22-dione; Geldanamycin analogue; Hsp90 Inhibitor Herbimycin C
EINECS	Contact for details

Quality Control

Our Herbimycin C is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (NMR, MS), and biological potency assessment. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Biological Activity	Assessed by Hsp90 inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.