Description

(15R)-18,21-Didehydro-17-Demethoxy-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin is a semi-synthetic derivative of the natural product geldanamycin, belonging to the benzoquinone ansamycin class of compounds. This molecule is of significant interest for its role as a key intermediate and research tool in the development of novel Heat Shock Protein 90 (Hsp90) inhibitors. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of targeted cancer therapeutics and other advanced biomedical research applications.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of next-generation Hsp90 inhibitor drug candidates for oncology research.
• Biochemical Research: Used as a reference standard and precursor in studies investigating the structure-activity relationships (SAR) of ansamycin antibiotics.
• Medicinal Chemistry: Serves as a scaffold for the design and development of novel analogs with potentially improved pharmacological profiles.
• Academic Research: Employed in university and institutional labs for fundamental studies on molecular chaperones, protein folding, and cellular stress response pathways.
• Process Development: Utilized by process chemists to optimize synthetic routes and scale-up protocols for complex ansamycin derivatives.

Basic Information

Product Name	(15R)-18,21-Didehydro-17-Demethoxy-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin
CAS No.	91700-91-3
Molecular Formula	C30H41NO8
Molecular Weight	543.65 g/mol
Synonyms	17-Demethoxy-18,21-dideoxy-18,21-dihydroxy-15-methoxygeldanamycin; 18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin; 15-Methoxy-17-demethoxy-18,21-dideoxy-18,21-dihydroxygeldanamycin; Geldanamycin derivative 91700-91-3; Ansamycin derivative; Hsp90 inhibitor intermediate; Benzoquinone ansamycin analog
EINECS	Contact for details

Quality Control

Our production of (15R)-18,21-Didehydro-17-Demethoxy-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity and spectroscopic data, are provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. The compound is light-sensitive; handling should be performed under appropriate light conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.