Description

9-Aminocamptothecin is a potent, semi-synthetic derivative of the natural alkaloid camptothecin, distinguished by its amino substitution at the 9-position. This structural modification enhances its pharmacological profile, making it a critical intermediate and reference standard in oncology research and drug development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on developing novel chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced camptothecin-based anticancer drugs.
• Biochemical Research: Used as a reference standard and tool compound in studies of topoisomerase I inhibition and DNA damage mechanisms.
• Anticancer Agent Development: Investigated for its intrinsic antitumor activity and as a lead compound for developing new chemotherapeutic candidates.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for quality control and quantification in pharmaceutical manufacturing.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles.

Basic Information

Product Name	9-Aminocamptothecin
CAS No.	91421-43-1
Molecular Formula	C20H17N3O4
Molecular Weight	363.37 g/mol
Synonyms	9-AC; 9-Amino-20(S)-camptothecin; (S)-9-Aminocamptothecin; 9-Amino-CPT; NSC 603071; 4-Ethyl-4-hydroxy-9-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 9-Aminocamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive (store away from light). Keep the container sealed in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.