Description

Rubitecan is a synthetic camptothecin derivative, a potent topoisomerase I inhibitor with significant research and development interest. This compound is valued for its targeted mechanism of action, which interferes with DNA replication in rapidly dividing cells. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers engaged in the development of novel oncology therapeutics and biochemical probes.

Application

• Pharmaceutical R&D: A key intermediate or active pharmaceutical ingredient (API) in the research and development of novel chemotherapeutic agents.
• Oncology Research: Used as a reference standard or biochemical tool in preclinical studies to investigate topoisomerase I inhibition and apoptosis mechanisms.
• Chemical Synthesis: Serves as a sophisticated building block for the synthesis of more complex camptothecin analogs and targeted drug conjugates.
• Biochemical Assays: Employed in in vitro assays to study DNA damage response, cell cycle arrest, and efficacy screening in cancer cell lines.

Basic Information

Product Name	Rubitecan
CAS No.	91421-42-0
Molecular Formula	C₂₃H₂₃N₃O₅
Molecular Weight	421.45 g/mol
Synonyms	9-Nitro-20(S)-camptothecin; 9-Nitro-camptothecin; RFS 2000; NSC 628503; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 9-nitro derivative; 9-Nitrocamptothecin; Rubitecanum
EINECS	Contact for details

Quality Control

Our Rubitecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.