Description

2,3,4,5,6-Pentamethylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the efficient formation of carbon-carbon bonds, introducing the sterically hindered pentamethylphenyl group into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise functionalization and the synthesis of complex, high-value intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs), particularly those requiring sterically demanding aromatic moieties to modulate biological activity and metabolic stability.
• Ligand Precursor in Catalysis: Serves as a precursor for synthesizing specialized phosphine and N-heterocyclic carbene (NHC) ligands used in homogeneous transition metal catalysis.
• Advanced Material Development: Used in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where the pentamethylphenyl group influences electronic properties and molecular packing.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides, introducing specific aromatic structures to enhance efficacy and environmental profile.
• Fine Chemical and Specialty Chemical Production: Facilitates the production of complex fragrance molecules, dyes, and other high-value specialty chemicals.
• Academic and R&D Laboratories: A critical tool for methodological development in organic chemistry and for exploring new reaction pathways in synthetic chemistry research.

Basic Information

Item	Detail
Product Name	2,3,4,5,6-Pentamethylphenylmagnesium Bromide
CAS No.	91345-58-3
Molecular Formula	C11H15BrMg
Molecular Weight	251.44 g/mol
Synonyms	Pentamethylphenylmagnesium Bromide; 2,3,4,5,6-Pentamethylbenzenemagnesium Bromide; 1,2,3,4,5-Pentamethyl-6-magnesiophenyl Bromide; Grignard Reagent (Pentamethylphenyl); (Pentamethylphenyl)magnesium Bromide; Magnesium, bromo(2,3,4,5,6-pentamethylphenyl)-; Bromo(pentamethylphenyl)magnesium
EINECS	Contact for details

Quality Control

Every batch of our 2,3,4,5,6-Pentamethylphenylmagnesium Bromide is manufactured and handled under stringent inert atmosphere conditions to ensure purity and reactivity. We employ advanced analytical techniques, including quantitative titration and GC/HPLC analysis, to verify concentration and assess impurity profiles. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring full traceability and compliance with your research or production quality standards.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at 2-8°C. For long-term stability, storage at lower temperatures (e.g., -20°C) under inert gas is recommended. The container should be kept in a cool, dry, well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	Clear to slightly colored solution
Concentration (in THF or Ether)	0.5 M - 1.0 M (Typical)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.