Description

Trimethylsilylmethylmagnesium Chloride is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its core value proposition lies in its ability to introduce the versatile trimethylsilylmethyl (TMS-CH2-) group, serving as a robust nucleophile and carbanion equivalent for constructing carbon-carbon bonds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient synthetic methodologies. Its utility is particularly noted in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and specialty silicon-containing compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing carbon skeletons in the development of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of novel pesticides, herbicides, and fungicides that require silicon-functionalized structures.
• Advanced Material Precursor: Serves as a building block for creating silicon-containing polymers, dendrimers, and specialty silicones with tailored properties.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions to aldehydes, ketones, and epoxides, as well as in cross-coupling reactions.
• Silyl Group Transfer Agent: Facilitates the introduction of the trimethylsilylmethyl group, a useful protecting group and functional handle in multi-step syntheses.
• Laboratory-Scale Research: A critical tool for academic and industrial R&D chemists exploring new synthetic pathways and reaction mechanisms.

Basic Information

Product Name	Trimethylsilylmethylmagnesium Chloride
CAS No.	13170-43-9
Molecular Formula	C4H11ClMgSi
Molecular Weight	146.98 g/mol
Synonyms	(Chloromethyl)trimethylsilane Magnesium; (Trimethylsilyl)methylmagnesium Chloride; Magnesium, chloromethyltrimethylsilyl-; TMS-CH2MgCl; Trimethylsilylmethyl Grignard Reagent; Trimethylsilylmethylmagnesium Chloride Solution; (Trimethylsilylmethyl)magnesium Chloride; Chloro(trimethylsilylmethyl)magnesium
EINECS	Contact for details

Quality Control

Our Trimethylsilylmethylmagnesium Chloride is manufactured under stringent quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including titration for Grignard concentration and GC analysis for solvent purity and by-products. A comprehensive Certificate of Analysis (COA) detailing assay, appearance, and solution concentration is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, a strong base in organic solvent, and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for prolonged stability. Keep away from heat, sparks, open flames, and incompatible materials such as moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95%
Identification (IR)	Conforms to structure
Solvent (Typical)	Tetrahydrofuran (THF) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.