Description

Magnesium, Bromocyclobutyl- is a highly reactive organomagnesium reagent, specifically a Grignard reagent, with the CAS number 13384-48-0. This compound is a critical building block in synthetic organic chemistry, enabling the formation of new carbon-carbon bonds to construct complex molecular frameworks. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive molecules, particularly those containing cyclobutyl or spirocyclic ring systems.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the cyclobutyl moiety imparts specific biological activity.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials that require rigid, aliphatic building blocks.
• Cross-Coupling Reactions: Serves as a nucleophilic coupling partner in Kumada, Negishi, and other transition metal-catalyzed cross-coupling reactions to form new C-C bonds.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters), epoxides, and nitriles to introduce the cyclobutyl group.
• Academic & Process R&D: A valuable tool for method development and scale-up studies in both academic laboratories and industrial process research and development.

Basic Information

Product Name	Magnesium, Bromocyclobutyl-
CAS No.	13384-48-0
Molecular Formula	C4H7BrMg
Molecular Weight	159.30 g/mol
Synonyms	Bromocyclobutylmagnesium; Cyclobutylmagnesium bromide; Magnesium bromocyclobutane; Grignard reagent, bromocyclobutyl-; (Bromocyclobutyl)magnesium; Cyclobutyl bromide magnesium; Bromocyclobutane magnesium turnings; CyclobutylMgBr
EINECS	Contact for details

Quality Control

Our Magnesium, Bromocyclobutyl- is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing to ensure high reactivity, consistent concentration, and purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing assay (typically by titration), solvent content, and other critical parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this product must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for prolonged stability. The container must be kept in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (Titration)	0.5 M to 3.0 M in specified solvent (e.g., THF, Diethyl ether)
Purity (GC/HPLC)	≥ 95% (relative area)
Solvent	As specified (Tetrahydrofuran, Diethyl ether)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.