Description

Propargylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its core value lies in its ability to introduce the versatile propargyl group, enabling the construction of complex molecular frameworks and carbon-carbon bonds. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to synthesize novel alkynes and other functionalized intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating active pharmaceutical ingredients (APIs) and complex organic molecules.
• Agrochemical Production: Used in the synthesis of herbicides, fungicides, and other crop protection agents.
• Material Science Research: Employed in the development of polymers, liquid crystals, and other functional materials with tailored properties.
• Organic Synthesis Reagent: Facilitates nucleophilic addition reactions to carbonyl compounds (aldehydes, ketones, esters) and epoxides.
• Alkyne Functionalization: Serves as a precursor for introducing terminal and internal alkyne functionalities into target molecules.
• Cross-Coupling Reactions: Acts as a coupling partner in various metal-catalyzed reactions for C-C bond formation.

Basic Information

Product Name	Propargylmagnesium Bromide
CAS No.	13254-27-8
Molecular Formula	C₃H₃MgBr
Molecular Weight	143.26 g/mol
Synonyms	Magnesium, bromo(2-propynyl)-; Bromo(2-propynyl)magnesium; 2-Propyn-1-ylmagnesium bromide; Propargyl Grignard reagent; Propargylmagnesium bromide solution; 1-Propynylmagnesium bromide; HC≡CCH₂MgBr
EINECS	Contact for details

Quality Control

Our Propargylmagnesium Bromide is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration for assay determination and impurity profiling, to ensure consistency and high reactivity. Certificates of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or ether), and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile, strong alkali/organic solvent that is easily oxidized, it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for extended stability. Keep away from heat, sparks, open flames, and incompatible materials such as moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to light yellow solution
Identification (IR)	Conforms
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on solvent-free basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.