Description

Neopentylmagnesium Chloride is a highly reactive organomagnesium compound, commonly known as a Grignard reagent, with the CAS number 13132-23-5. It serves as a critical building block in organic synthesis, valued for its ability to introduce the bulky, sterically hindered neopentyl group into target molecules. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise carbon-carbon bond formation and the synthesis of complex, high-value intermediates.

Application

Neopentylmagnesium Chloride is a versatile reagent used in a variety of synthetic transformations. Its primary applications include:

• Pharmaceutical Intermediate Synthesis: Key for constructing sterically hindered carbon centers in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where the neopentyl moiety imparts specific biological activity and stability.
• Polymer & Material Science: Acts as an initiator or chain-transfer agent in the synthesis of specialized polymers and as a precursor for organometallic catalysts.
• Fine Chemical Production: Employed in the synthesis of complex fragrances, flavors, and other high-value specialty chemicals.
• Academic & Industrial R&D: A fundamental tool for exploring new organic reactions and methodologies in research laboratories.

Basic Information

Product Name	Neopentylmagnesium Chloride
CAS No.	13132-23-5
Molecular Formula	C5H11ClMg
Molecular Weight	130.90 g/mol
Synonyms	Chloroneopentylmagnesium; Magnesium, chloroneopentyl-; (2,2-Dimethylpropyl)magnesium chloride; Neopentyl Grignard reagent; 1-Chloro-2,2-dimethylpropane magnesium; (Neopentyl)MgCl; 2,2-Dimethylpropylmagnesium chloride
EINECS	Contact for details

Quality Control

Our Neopentylmagnesium Chloride is manufactured under stringent quality protocols. Each batch undergoes rigorous analytical testing, including titration for assay determination and GC analysis for solvent and impurity profiles, to ensure consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality management system is designed to meet the exacting standards of cGMP and ISO-guided environments for reliable performance in your sensitive synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, a strong base in organic solvent, and easily oxidized. It must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area, away from heat, moisture, and incompatible materials. For optimal stability and to prevent concentration changes due to volatility, storage at 2-8°C is recommended. Always handle and open containers under an inert atmosphere using appropriate techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR/NMR)	Conforms to structure
Solvent (as specified)	Meets purity requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.