Description

3,4-Difluorophenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in enabling the precise introduction of the 3,4-difluorophenyl moiety, a key structural motif known to enhance the metabolic stability and binding affinity of target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infectives where the difluorophenyl group is prevalent.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where fluorinated aromatic rings improve compound efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a critical reagent in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Employed in Kumada, Negishi, and other transition-metal catalyzed cross-coupling reactions to create biaryl and complex polycyclic structures.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (aldehydes, ketones, esters), epoxides, and other electrophiles to form alcohols and extended carbon skeletons.
• Custom & Contract Manufacturing: Essential for fine chemical and custom synthesis houses producing tailored intermediates for client-specific R&D projects.

Basic Information

Product Name	3,4-Difluorophenylmagnesium Bromide
CAS No.	90897-92-0
Molecular Formula	C6H3F2MgBr
Molecular Weight	217.30 g/mol
Synonyms	Magnesium, bromo(3,4-difluorophenyl)-; (3,4-Difluorophenyl)magnesium bromide; 3,4-Difluorophenylmagnesium bromide solution; Grignard reagent 3,4-difluorophenyl; 3,4-DFPMgBr; 90897-92-0; 3,4-Difluorobenzene, bromomagnesio-
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylmagnesium Bromide is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Quality is assured through rigorous in-process and final testing, including titration for concentration and GC analysis for solvent and impurity profiles. A Certificate of Analysis (COA) detailing concentration, purity, and solvent specifications is provided with each shipment to support your quality management systems.

Storage

Preserve in a tightly closed container under an inert atmosphere (argon or nitrogen), protected from light. Store at 2-8°C. This material is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized. Keep away from heat, sparks, open flames, and strong oxidizing agents. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (of stated concentration)
Solvent	Specified (Typical: Tetrahydrofuran, Diethyl ether)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.