Description

Corticotropin Releasing Factor Antagonist CAS NO 90880-23-2 is a potent and selective synthetic peptide designed to inhibit the corticotropin-releasing factor (CRF) receptor, a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis. This compound is critical for advanced research into stress-related disorders, anxiety, depression, and addiction pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroendocrinology and central nervous system (CNS) drug discovery.

Application

• Neuroscientific Research: Fundamental tool for studying the role of CRF in stress response, anxiety, and depression models in vitro and in vivo.
• Drug Discovery & Preclinical Development: Used as a reference standard or pharmacological probe in high-throughput screening (HTS) and lead optimization for novel CNS therapeutics.
• Behavioral Pharmacology: Investigation of CRF receptor antagonism effects on addiction, feeding behavior, and learning/memory processes.
• Endocrine Studies: Research into HPA axis dysregulation and its connection to metabolic syndromes and inflammatory conditions.
• Biomarker Assay Development: Serves as a critical component in developing and validating diagnostic assays for stress-related biomarkers.

Basic Information

Product Name	Corticotropin Releasing Factor Antagonist
CAS No.	90880-23-2
Molecular Formula	C184H301N55O51S
Molecular Weight	4108.8 g/mol
Synonyms	Astressin; Cyclo(30-33)[Ac-Pro30,D-Phe32,Nle33]Ac-Sauvagine(30-41); Astressin (human, rat); h/r Astressin; CRF Antagonist Astressin; Ac-[Pro30,D-Phe32,Nle33]Ac-Sauvagine(30-41); Cyclo(30-33)[Ac-Pro30,D-Phe32,Nle33]r/hCRF(30-41)
EINECS	Contact for details

Quality Control

Every batch of our Corticotropin Releasing Factor Antagonist is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and biological activity, with specifications typically meeting or exceeding >95% purity (by HPLC). Certificates of Analysis (COA) detailing batch-specific results for assay, related substances, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This hygroscopic (moisture-sensitive) material should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Confirmed by in vitro receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.