Description

2',4'-Dichlorobenzamil Amiloride is a potent and selective inhibitor of the sodium-calcium exchanger (NCX), widely used as a key research tool in cardiovascular and neurological studies. Its high specificity makes it invaluable for investigating calcium signaling pathways, ion channel function, and related cellular mechanisms. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on cardiac physiology, neuroprotection, and drug discovery.

Application

• Pharmacological Research: A critical tool for studying the role of the sodium-calcium exchanger (NCX) in cardiac myocytes, neurons, and other cell types.
• Cardiovascular Studies: Used to investigate ischemia-reperfusion injury, heart failure, and arrhythmias by modulating intracellular calcium levels.
• Neuroscience Research: Applied in models of stroke, excitotoxicity, and neurodegenerative diseases to understand calcium-mediated cell death.
• Cell Signaling Pathway Analysis: Employed to dissect calcium-dependent signaling cascades and their physiological impacts.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe for screening and validating new NCX-targeting therapeutics.
• Biochemical Assay Development: Utilized in the creation and validation of high-throughput screening assays for ion channel modulators.

Basic Information

Product Name	2',4'-Dichlorobenzamil Amiloride
CAS No.	90689-42-2
Molecular Formula	C18H17Cl2N5O2
Molecular Weight	414.27 g/mol
Synonyms	2',4'-Dichlorobenzamil; Benzamil, 2',4'-Dichloro-; 2',4'-Dichloro-N-(diaminomethylene)benzamil; 2',4'-Dichlorobenzamil; NCX Inhibitor; Sodium-Calcium Exchanger Inhibitor; Amiloride analog; 3,5-Diamino-N-(aminoiminomethyl)-6-chloro-N-(2,4-dichlorobenzyl)pyrazinecarboxamide
EINECS	Contact for details

Quality Control

Our 2',4'-Dichlorobenzamil Amiloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.