Description

4,4-Difluororetinoic Acid is a fluorinated derivative of retinoic acid, a compound of significant interest in advanced pharmaceutical research and development. This modification enhances metabolic stability and alters biological activity, making it a valuable synthetic intermediate for creating novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of retinoid-based treatments for oncology, dermatology, and other specialized medical fields.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel retinoid receptor agonists and antagonists for drug discovery.
• Biochemical Research: Used as a reference standard and active probe in studies of retinoid signaling pathways and nuclear receptor function.
• Oncology Research: Investigated for its potential role in the development of differentiation therapies and chemopreventive agents targeting various cancers.
• Dermatological R&D: Serves as a precursor in the development of next-generation topical treatments for conditions like acne, psoriasis, and photoaging.
• Metabolic Studies: Employed to study the structure-activity relationships (SAR) of fluorinated retinoids and their pharmacokinetic profiles.

Basic Information

Product Name	4,4-Difluororetinoic Acid
CAS No.	90660-20-1
Molecular Formula	C20H26F2O2
Molecular Weight	336.42 g/mol
Synonyms	4,4-Difluoro-retinoic acid; (2E,4E,6E,8E)-9-(4,4-Difluoro-3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; 4,4-Difluoro all-trans-retinoic acid; 4,4-Difluoro ATRA; DF-ATRA; 4,4-Difluoro Tretinoin
EINECS	Contact for details

Quality Control

Our 4,4-Difluororetinoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high purity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.