Description

4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-Oxyl (D17, 15N) is a stable, isotopically labeled nitroxide radical, specifically deuterated and nitrogen-15 enriched, serving as a critical spin probe and standard in advanced spectroscopic research. This compound is essential for providing unparalleled precision in Electron Paramagnetic Resonance (EPR) and Dynamic Nuclear Polarization (DNP) experiments, enabling detailed structural and dynamic studies of complex molecular systems. It is primarily utilized by research institutions, pharmaceutical developers, and advanced material scientists requiring high-fidelity, site-specific labeling for mechanistic investigations and method validation.

Application

• EPR Spectroscopy Standard: Acts as a primary reference and calibration standard for g-factor and hyperfine coupling constant measurements.
• Dynamic Nuclear Polarization (DNP): Used as a polarizing agent to dramatically enhance NMR signal sensitivity in solid-state and solution-state NMR.
• Spin Labeling: Employed to site-specifically label biomolecules (proteins, nucleic acids) or synthetic polymers to study conformation, dynamics, and interactions via EPR.
• Oxidation & Radical Chemistry Research: Serves as a stable radical tracer or model compound in studies of redox processes and free radical mechanisms.
• Polymer Science: Utilized as a probe to investigate polymerization kinetics, polymer chain mobility, and degradation processes.
• Membrane Biophysics: Applied to study lipid bilayer properties, membrane fluidity, and protein-membrane interactions.
• Method Development: Critical for developing and validating new EPR/NMR methodologies and pulse sequences due to its well-defined spectral properties.
• Quality Control: Used in-house by manufacturers of EPR instrumentation to verify system performance and sensitivity.

Basic Information

Product Name	4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-Oxyl (D17, 15N)
CAS No.	90429-66-6
Molecular Formula	C9D1715NO2
Molecular Weight	~188.3 g/mol
Synonyms	4-Hydroxy-TEMPO-d17-15N; 4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl-d17-15N; 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy-d17-15N; 4-Hydroxy TEMPO-d17-15N; 4-HTEMPO-d17-15N; 4-OH-TEMPO-d17-15N; (2,2,6,6-Tetramethyl-4-piperidinol-1-oxyl)-d17-15N; Perdeuterated, 15N-labeled 4-Hydroxy-TEMPO
EINECS	Contact for details

Quality Control

Every batch of our isotopically labeled 4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-Oxyl (D17, 15N) is produced and analyzed under strict quality protocols to ensure exceptional chemical purity and isotopic enrichment. We guarantee compliance with rigorous internal specifications, supported by comprehensive analytical data including NMR (1H, 13C), EPR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting purity, isotopic enrichment (D and 15N), and spectral properties is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container sealed in a dry, cool, and well-ventilated place. For long-term storage, consider storage at -20°C.

Specification

Item	Specification
Appearance	Orange to red crystalline solid or powder
Identification (IR)	Conforms to reference spectrum
Identification (EPR)	Characteristic triplet signal
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom % 15N
Deuterium Enrichment (D)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.