Description

(+)-Indolactam V CAS NO 90365-56-3 is a potent and specific activator of protein kinase C (PKC), belonging to the class of indole alkaloid lactams. This compound is a critical research-grade biochemical tool for studying intracellular signaling pathways, cellular differentiation, and tumor promotion mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in cancer biology and neuroscience.

Application

• Biochemical Research: A key tool for investigating the role of Protein Kinase C (PKC) isoforms in signal transduction, cell proliferation, and apoptosis.
• Oncology Studies: Used to model PKC-mediated tumor promotion and to screen for potential PKC inhibitors as anticancer agents.
• Neuroscience Research: Applied in studies of neurotransmitter release, neuronal plasticity, and the effects of PKC activation on memory and learning.
• Cardiovascular Research: Employed to examine PKC's role in cardiac hypertrophy, vascular smooth muscle contraction, and heart failure pathways.
• Inflammatory Response Modeling: Used to activate PKC in immune cells to study its function in inflammation and immune regulation.
• Stem Cell & Differentiation Studies: Serves as an agent to induce differentiation in various cell lines by modulating PKC activity.
• High-Throughput Screening (HTS): Utilized as a reference standard or positive control in drug discovery assays targeting the PKC pathway.
• Toxicology Assessments: Acts as a model compound for studying the mechanisms of certain tumor-promoting toxins.

Basic Information

Product Name	(+)-Indolactam V
CAS No.	90365-56-3
Molecular Formula	C19H24N4O2
Molecular Weight	340.42 g/mol
Synonyms	Indolactam V; Teleocidin V; (-)-Indolactam V (enantiomer); L-156,602; PKC Activator I; (12S,13S)-(-)-12,13-Epoxy-3-methoxy-10-methyl-11-oxo-11H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dicarbonitrile; Teleocidin A-2
EINECS	Contact for details

Quality Control

Our (+)-Indolactam V is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.