Description

Ofloxacin o-Glucuronide is a crucial metabolite and reference standard of the fluoroquinolone antibiotic ofloxacin. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily used by analytical laboratories, pharmaceutical manufacturers, and research institutions involved in drug discovery and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of ofloxacin metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance, and bioavailability of ofloxacin.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating HPLC, LC-MS, and other analytical methods in clinical and preclinical studies.
• Impurity Profiling: Employed in the quality control of ofloxacin API and finished drug products to monitor and control related substances.
• Toxicology Research: Used in studies to understand the safety profile and potential toxicological implications of ofloxacin metabolites.

Basic Information

Product Name	Ofloxacin o-Glucuronide
CAS No.	90293-81-5
Molecular Formula	C25H28FN3O11
Molecular Weight	565.51 g/mol
Synonyms	Ofloxacin Glucuronide; Ofloxacin O-β-D-Glucuronide; 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid β-D-glucopyranosiduronic acid; Ofloxacin D-Glucuronide; Ofloxacin Metabolite M4; (RS)-Ofloxacin Glucuronide
EINECS	Contact for details

Quality Control

Our Ofloxacin o-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research and pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.