Description

3-Fluoro-4-Methylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, introducing the sulfonyl functional group to create sulfonamides and sulfonate esters with high efficiency. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients, intermediates, and fine chemicals requiring specific fluorinated aromatic architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs with potential antibacterial, diuretic, or anticancer properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine and sulfonyl chloride groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the production of specialty polymers, liquid crystals, and advanced materials that benefit from fluorinated aromatic sulfone units.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling proteins or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Dye and Pigment Manufacturing: Serves as an intermediate for synthesizing sulfonated dyes and pigments, where it helps improve solubility and color fastness.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CROs (Contract Research Organizations) working on client-specific fluorinated target molecules.

Basic Information

Product Name	3-Fluoro-4-Methylbenzenesulfonyl Chloride
CAS No.	90260-13-2
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	4-Methyl-3-fluorobenzenesulfonyl chloride; 3-Fluoro-p-toluenesulfonyl chloride; 3-Fluoro-4-methylbenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-3-fluoro-4-methylbenzene; 3-Fluoro-4-methylphenylsulfonyl chloride; 3-Fluoro-4-toluenesulfonyl chloride; 90260-13-2; 3-Fluoro-4-methylbenzenesulphonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.