Description

Alphostatin CAS NO 90119-88-3 is a synthetic peptide compound known for its potent biological activity as a selective inhibitor of matrix metalloproteinases (MMPs). This compound is of significant value in biochemical and pharmaceutical research for studying cellular processes related to tissue remodeling, angiogenesis, and metastasis. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing novel therapeutic agents for cancer and inflammatory diseases.

Application

• Biomedical Research: Used as a key research tool to investigate the role of specific matrix metalloproteinases (MMPs) in disease pathology, including cancer invasion and metastasis.
• Drug Discovery & Development: Serves as a reference standard or lead compound in screening assays and structure-activity relationship (SAR) studies for novel MMP inhibitors.
• Enzymology Studies: Employed in in vitro enzymatic assays to determine inhibition constants (Ki) and study enzyme kinetics of MMP family members.
• Cell Culture & Tissue Engineering: Applied in cell-based models to modulate extracellular matrix (ECM) degradation and study its effects on cell migration, proliferation, and differentiation.
• Preclinical Research: Utilized in animal models of disease to evaluate the therapeutic potential of MMP inhibition for conditions like rheumatoid arthritis, atherosclerosis, and tumor progression.

Basic Information

Item	Details
Product Name	Alphostatin
CAS No.	90119-88-3
Molecular Formula	C34H49N7O9S
Molecular Weight	731.86 g/mol
Synonyms	N-Acetyl-L-cysteinyl-L-valyl-L-asparaginyl-L-isoleucyl-L-threonyl-L-cysteinyl-L-threonyl-L-prolyl-L-leucylglycine cyclic (1→7)-disulfide; MMP Inhibitor I; CAS 90119-88-3; Cyclo(1,7)-[Cys-Val-Asn-Ile-Thr-Cys-Thr-Pro-Leu-Gly]; Ac-CVNITCTPLG (cyclic 1-7 disulfide); Peptide MMP Inhibitor
EINECS	Contact for details

Quality Control

Our Alphostatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.