Description

Ala-Ala-Pro-Val-Cmk CAS NO 90105-47-8 is a specialized peptide-based chloromethyl ketone inhibitor, a potent and irreversible active-site directed agent. This compound is of significant value in biochemical and pharmaceutical research for its specific mechanism of action. It is primarily utilized by researchers in proteomics, enzymology, and medicinal chemistry for studying serine protease activity and developing targeted therapeutic agents.

Application

• Biochemical Research: As a specific, irreversible inhibitor for studying the kinetics, structure, and function of target serine proteases.
• Protease Mechanism Studies: Used to elucidate catalytic mechanisms and active site characterization of enzymes like dipeptidyl peptidase IV (DPP-IV) and related proteases.
• Medicinal Chemistry & Drug Discovery: Serves as a key pharmacophore or lead compound in the development of novel protease inhibitors for therapeutic applications.
• Cell Biology & Signal Transduction: Employed to inhibit specific proteolytic pathways in cellular systems to understand their role in physiological and pathological processes.
• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	Ala-Ala-Pro-Val-Cmk
CAS No.	90105-47-8
Molecular Formula	C19H33ClN4O5
Molecular Weight	432.94 g/mol
Synonyms	Ala-Ala-Pro-Val Chloromethyl Ketone; L-Alanyl-L-alanyl-L-prolyl-L-valine chloromethyl ketone; AAPV-CMK; DPP-IV Inhibitor I; H-Ala-Ala-Pro-Val-CH2Cl; N-[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-1-oxopropan-2-yl]amino]-3-chloro-1-oxopropan-2-yl]alanine; Dipeptidyl Peptidase IV Inhibitor I
EINECS	Contact for details

Quality Control

Our Ala-Ala-Pro-Val-Cmk is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical documentation, including HPLC chromatograms and mass spectrometry data. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each batch to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.