Description

Z-L-Val-Chloromethylketone is a specialized peptide-derived chloromethyl ketone, a crucial building block and protease inhibitor scaffold in advanced biochemical research and pharmaceutical development. Its value lies in its high reactivity and specificity, enabling the synthesis of targeted enzyme inhibitors and the study of proteolytic mechanisms. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on drug discovery, particularly for developing treatments for conditions involving dysregulated protease activity.

Application

• Protease Inhibitor Synthesis: A key intermediate in the design and production of potent, irreversible inhibitors for serine and cysteine proteases.
• Pharmaceutical Research & Development: Used as a critical scaffold in medicinal chemistry for creating candidate drug molecules targeting specific enzymatic pathways.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate protease structure, function, and inhibition kinetics.
• Peptide Chemistry: Serves as a reactive building block for the synthesis of more complex peptide analogs and conjugates.
• Antiviral & Anticancer Agent Development: Explored in research for developing therapeutic agents that work by inhibiting viral replication or tumor-associated proteases.

Basic Information

Product Name	Z-L-Val-Chloromethylketone
CAS No.	90105-41-2
Molecular Formula	C14H18ClNO4
Molecular Weight	299.75 g/mol
Synonyms	Z-Val-CH2Cl; Benzyloxycarbonyl-L-valyl chloromethyl ketone; N-Carbobenzoxy-L-valyl chloromethyl ketone; Z-L-Valine chloromethyl ketone; (S)-1-(((Benzyloxy)carbonyl)amino)-3-methyl-1-oxobutan-2-yl chloromethyl ketone; CBZ-Val-CH2Cl; N-CBZ-L-Valyl Chloromethyl Ketone; Protease Inhibitor Z-Val-CH2Cl
EINECS	Contact for details

Quality Control

Our Z-L-Val-Chloromethylketone is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.