Description

Imd-0354 is a potent and selective small molecule inhibitor of IκB kinase β (IKKβ), a key regulator of the NF-κB signaling pathway. This compound is a critical research tool for investigating inflammatory responses, cell survival, and oncogenesis in preclinical studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for cancer, autoimmune, and inflammatory diseases.

Application

• Biomedical Research: A key pharmacological probe for studying the NF-κB pathway's role in cellular signaling, inflammation, and apoptosis.
• Oncology Research: Used in vitro and in vivo to investigate the inhibition of tumor growth, metastasis, and to sensitize cancer cells to chemotherapy.
• Inflammatory Disease Models: Applied in research models for rheumatoid arthritis, asthma, and other chronic inflammatory conditions to assess therapeutic potential.
• Drug Discovery & Development: Serves as a reference compound or lead structure for the design and screening of new IKKβ inhibitors.
• Cell Biology Studies: Utilized to elucidate the molecular mechanisms linking inflammation, immunity, and cell proliferation.

Basic Information

Product Name	Imd-0354
CAS No.	978-62-1
Molecular Formula	C₂₀H₂₁N₅O₂
Molecular Weight	363.41 g/mol
Synonyms	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide; IMD 0354; IMD0354; IKK-2 Inhibitor V; N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide; BAY 11-7082 analog; IKKβ Inhibitor, IMD 0354
EINECS	Contact for details

Quality Control

Our Imd-0354 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.