Description

1,3-Dimethyluric Acid is a key methylated xanthine derivative, serving as a significant metabolite of caffeine and theophylline. This high-purity reference standard is essential for analytical and research applications requiring precise quantification and metabolic pathway studies. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic institutions focused on purine metabolism and pharmacokinetics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of caffeine and theophylline metabolites in drug development and bioequivalence studies.
• Clinical Diagnostics: Serves as a calibrator and control in liquid chromatography-mass spectrometry (LC-MS/MS) assays for therapeutic drug monitoring (TDM) in patient serum or plasma.
• Biochemical Research: Employed in studies investigating the enzymatic pathways of xanthine oxidase and other purine metabolic enzymes.
• Toxicology & Forensics: Acts as a biomarker in analytical methods for assessing caffeine intake, overdose cases, or substance abuse panels.
• Academic & Method Development: Provides a pure compound for university research, method validation, and the development of new analytical protocols in pharmacokinetics.

Basic Information

Product Name	1,3-Dimethyluric Acid
CAS No.	944-73-0
Molecular Formula	C7H8N4O3
Molecular Weight	196.16 g/mol
Synonyms	1,3-Dimethyluric Acid; 1,3-Dimethyl-2,6,8-trihydroxypurine; 1,3-Dimethyl-7,9-dihydro-1H-purine-2,6,8(3H)-trione; Theophylline Metabolite; Caffeine Metabolite; 1,3-Dimethyl-2,6,8-trioxopurine; 1,3-Dimethyl-2,6,8-trihydroxypurine; 1,3-Dimethyl-2,6,8(1H,3H,9H)-purinetrione
EINECS	213-401-5

Quality Control

Our 1,3-Dimethyluric Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.