Description

4-Trifluoromethylbenzyl Chloride is a versatile and high-value organofluorine building block essential for advanced chemical synthesis. Its primary value lies in the introduction of the trifluoromethylbenzyl moiety, a key structural feature that can dramatically alter the physical, chemical, and biological properties of target molecules. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its ability to modify electronic properties and stability.
• Polymer & Resin Modifier: Incorporated to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Cross-coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Ligand & Catalyst Preparation: Used to synthesize fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Item	Detail
Product Name	4-Trifluoromethylbenzyl Chloride
CAS No.	939-99-1
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	α-Chloro-4-(trifluoromethyl)toluene; (4-Trifluoromethylphenyl)methyl Chloride; 4-(Chloromethyl)benzotrifluoride; p-Trifluoromethylbenzyl Chloride; 1-(Chloromethyl)-4-(trifluoromethyl)benzene; 4-(Trifluoromethyl)benzyl Chloride; Benzene, 1-(chloromethyl)-4-(trifluoromethyl)-; NSC 406908
EINECS	213-369-4

Quality Control

Our 4-Trifluoromethylbenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets precise customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The compound is moisture-sensitive; keep container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.35 - 1.39 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.