Description

4-Nitrobenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonating agent, facilitating the introduction of the 4-nitrobenzenesulfonyl (nosyl) protecting group for amines and other nucleophiles. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create intermediates for active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of sulfonamide drugs and other active pharmaceutical ingredients (APIs).
• Peptide & Amino Acid Chemistry: Used as the Nosyl (Ns) protecting group for amines during complex peptide synthesis.
• Agrochemical Synthesis: Building block for creating sulfonylurea-based herbicides and other crop protection agents.
• Dye & Pigment Manufacturing: Intermediate in the production of sulfonated azo dyes and other colored compounds.
• Polymer Modification: Employed to introduce sulfonyl functional groups into polymer chains for specialized material properties.
• Chemical Research & Development: A fundamental tool in organic synthesis laboratories for constructing complex molecular architectures.

Basic Information

Product Name	4-Nitrobenzenesulfonyl Chloride
CAS No.	98-74-8
Molecular Formula	C6H4ClNO4S
Molecular Weight	221.62 g/mol
Synonyms	p-Nitrobenzenesulfonyl chloride; 4-Nitrobenzene-1-sulfonyl chloride; Nosyl chloride; NSC 9790; Benzenesulfonyl chloride, 4-nitro-; p-Nosyl chloride; 4-Nitrobenzenesulphonyl chloride; 1-Chlorosulfonyl-4-nitrobenzene
EINECS	202-698-1

Quality Control

Our 4-Nitrobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed to exclude moisture. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	74 - 78 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.