Description

4-Iodobenzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the sulfonyl chloride group acts as a powerful electrophile for sulfonamide formation and the iodine atom provides a handle for further cross-coupling transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with sulfonylurea or sulfonamide backbones.
• Material Science: Employed in the creation of functional polymers and advanced materials with specific surface properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation, labeling biomolecules, or as part of activity-based probes.
• Cross-Coupling Reactions: The iodine substituent makes it a valuable substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, or Heck couplings to build complex biaryl systems.
• Dye & Pigment Manufacturing: Serves as an intermediate in the synthesis of specialized dyes and colorants.

Basic Information

Product Name	4-Iodobenzenesulfonyl Chloride
CAS No.	98-61-3
Molecular Formula	C6H4ClIO2S
Molecular Weight	302.52 g/mol
Synonyms	p-Iodobenzenesulfonyl chloride; Benzenesulfonyl chloride, 4-iodo-; 4-Iodophenylsulfonyl chloride; 1-Iodo-4-(chlorosulfonyl)benzene; Iodobenzene-4-sulfonyl chloride; 98-61-3; p-Iodophenylsulfonyl chloride
EINECS	202-687-6

Quality Control

Our 4-Iodobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, appearance, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.