Description

4-Chloro-Benzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced chemical synthesis. Its unique structure, featuring both a chloro and a trifluoromethyl substituent, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is essential for manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the production of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to pesticidal activity.
• Liquid Crystal & OLED Material Precursor: Serves as a fundamental building block for fluorinated compounds used in electronic display technologies and organic light-emitting diodes.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments, where its aromatic core allows for color development and functionalization.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine-containing groups into polymers, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for creating complex biaryl structures common in many advanced materials.

Basic Information

Product Name	4-Chloro-Benzotrifluoride
CAS No.	94-56-4
Molecular Formula	C7H4ClF3
Molecular Weight	180.55 g/mol
Synonyms	1-Chloro-4-(trifluoromethyl)benzene; p-Chloro-α,α,α-trifluorotoluene; 4-Chloro-α,α,α-trifluorotoluene; p-Chlorobenzotrifluoride; PCBTF; 4-Chloro(trifluoromethyl)benzene; (4-Chlorophenyl)trifluoromethane; NSC 8765
EINECS	202-340-1

Quality Control

Our 4-Chloro-Benzotrifluoride is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency that meets the exacting requirements of fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.5%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 1.5%
Density (at 20°C)	1.35 - 1.37 g/mL
Refractive Index (n20D)	1.446 - 1.450

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.