Description

(5-Difluoromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester is a high-value, protected amine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethylpyridine scaffold introduces desirable metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Chemical Biology: Used in the preparation of probes and ligands for target identification and validation studies.
• Material Science Research: Precursor for novel functionalized polymers and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	(5-Difluoromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	899899-70-8
Molecular Formula	C12H16F2N2O2
Molecular Weight	258.27 g/mol
Synonyms	tert-Butyl N-(5-(difluoromethyl)pyridin-3-yl)carbamate; 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)-3-pyridinylcarbamic Acid 1,1-Dimethylethyl Ester; N-Boc-5-(difluoromethyl)pyridin-3-amine; Boc-5-(difluoromethyl)-3-aminopyridine; 899899-70-8; (5-Difluoromethyl-3-pyridyl)-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (5-Difluoromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.