Description

5-(Difluoromethyl)Pyridin-3-Amine is a high-purity, versatile pyridine derivative featuring a reactive difluoromethyl group and an amine functionality. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the synthesis of novel active ingredients with enhanced properties. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the difluoromethyl group for improved metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Fluorine Chemistry Building Block: Essential for introducing the difluoromethyl motif into complex molecules, a valuable strategy in medicinal chemistry for modulating lipophilicity and metabolic profiles.

Basic Information

Product Name	5-(Difluoromethyl)Pyridin-3-Amine
CAS No.	899898-94-3
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	3-Amino-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)-3-pyridinamine; 3-Pyridinamine, 5-(difluoromethyl)-; 5-Difluoromethyl-pyridin-3-ylamine; 899898-94-3; 5-(Difluoromethyl)-3-aminopyridine; 3-Amino-5-difluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with client specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.