Description

1-Chloro-2-(Chloromethyl)-4-Fluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both chloro and chloromethyl substituents on a fluorobenzene ring, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluorobenzene or benzyl chloride pharmacophore.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the halogenated benzene core provides bioactivity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures.
• Polymer Modification: Employed to introduce functional groups into polymer chains, modifying properties like solubility and thermal stability.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution and further functionalization reactions to create more complex, multi-substituted benzene derivatives.

Basic Information

Product Name	1-Chloro-2-(Chloromethyl)-4-Fluorobenzene
CAS No.	898910-40-2
Molecular Formula	C7H5Cl2F
Molecular Weight	179.02 g/mol
Synonyms	2-Chloromethyl-1-chloro-4-fluorobenzene; 4-Fluoro-2-(chloromethyl)chlorobenzene; 1-Chloro-4-fluoro-2-(chloromethyl)benzene; 2-(Chloromethyl)-1-chloro-4-fluorobenzene; 4-Fluoro-α,2-dichlorotoluene; Benzene, 1-chloro-2-(chloromethyl)-4-fluoro-; α,2-Dichloro-4-fluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(Chloromethyl)-4-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and reactivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.