Description

2-Fluoro-4-Iodonicotinonitrile is a versatile halogenated pyridine derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on the pyridine-3-carbonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a key building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Used in the creation of specialized ligands for catalysis and in the development of organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl/alkynyl groups.
• Nucleophilic Substitution: The fluorine atom can be selectively displaced by various nucleophiles, enabling efficient derivatization of the pyridine ring.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	2-Fluoro-4-Iodonicotinonitrile
CAS No.	898854-59-6
Molecular Formula	C6H2FIN2
Molecular Weight	247.99 g/mol
Synonyms	4-Iodo-2-fluoropyridine-3-carbonitrile; 3-Cyano-4-iodo-2-fluoropyridine; 2-Fluoro-4-iodo-3-pyridinecarbonitrile; 2-Fluoro-4-iodonicotinonitrile; 898854-59-6; 4-Iodo-2-fluoro-3-cyanopyridine; 2-Fluoro-4-iodo-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodonicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.