Description

Ethyl 5-Trifluoroacetyl-2-Furanoate is a high-value fluorinated furan derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the reactive trifluoroacetyl group, which enables efficient introduction of fluorine atoms to enhance the metabolic stability and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex heterocyclic scaffolds and novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine moiety improves efficacy and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and coatings with unique surface properties.
• Fluorine Chemistry Research: A versatile reagent for studying nucleophilic acyl substitution reactions and developing new fluorination methodologies.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fine Chemical Production: Intermediate for synthesizing complex flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Ethyl 5-Trifluoroacetyl-2-Furanoate
CAS No.	898787-41-2
Molecular Formula	C9H7F3O4
Molecular Weight	236.15 g/mol
Synonyms	Ethyl 5-(Trifluoroacetyl)-2-furoate; 2-Furancarboxylic acid, 5-(trifluoroacetyl)-, ethyl ester; Ethyl 5-(trifluoroacetyl)furan-2-carboxylate; 5-Trifluoroacetyl-2-furanoic acid ethyl ester; Ethyl α,α,α-trifluoroacetylfuran-2-carboxylate; Furan-2-carboxylic acid, 5-(2,2,2-trifluoroacetyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Trifluoroacetyl-2-Furanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.