Description

At9283 CAS NO 896466-76-5 is a potent and selective small-molecule inhibitor targeting Aurora kinases A and B, which are key regulators of cell cycle progression. This compound is of significant value for research into cell division, oncology, and targeted cancer therapy development. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on discovering novel anti-cancer agents and studying mitotic regulation.

Application

• Biochemical Research: Used as a critical tool compound to study the biological functions and signaling pathways of Aurora kinases in vitro.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for developing new anti-cancer therapeutics.
• Cell Biology Studies: Employed to induce mitotic arrest and apoptosis in cancer cell lines, facilitating research into cell cycle checkpoints and mechanisms of genomic instability.
• Preclinical Development: Utilized in animal model studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of Aurora kinase inhibition.

Basic Information

Product Name	At9283
CAS No.	896466-76-5
Molecular Formula	C₂₁H₂₀BrN₅O₂
Molecular Weight	454.32 g/mol
Synonyms	AT-9283; AT 9283; 1H-Pyrrolo[2,3-b]pyridine, 3-[(7-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-1,3-dihydro-2H-indol-2-one; Aurora Kinase Inhibitor AT9283; 3-[(7-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-1,3-dihydro-2H-indol-2-one; 3-[(7-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]indolin-2-one
EINECS	Contact for details

Quality Control

Our At9283 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.