Description

Methyl 2-Bromo-5-(Trifluoromethyl)Nicotinate is a high-value, multi-functional chemical intermediate characterized by its bromo and trifluoromethyl substituents on a nicotinate core. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Functional Group Transformation: The ester group allows for further derivatization to carboxylic acids, amides, or alcohols, expanding its utility in medicinal chemistry.

Basic Information

Product Name	Methyl 2-Bromo-5-(Trifluoromethyl)Nicotinate
CAS No.	888738-49-6
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)nicotinic acid methyl ester; Methyl 2-bromo-5-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-bromo-5-(trifluoromethyl)-, methyl ester; 888738-49-6; Methyl 2-bromo-5-trifluoromethylnicotinate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-5-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.