Description

[6-(2,5-Difluorophenyl)Pyridin-3-Yl]Methanol is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in its unique bifunctional structure, which serves as a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides, where the difluorophenyl and pyridine motifs enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals with tailored electronic or optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to introduce complex aromatic systems into target molecules.
• Chemical Biology Probe Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fragment in fragment-based drug discovery (FBDD).

Basic Information

Product Name	[6-(2,5-Difluorophenyl)Pyridin-3-Yl]Methanol
CAS No.	887974-88-1
Molecular Formula	C12H9F2NO
Molecular Weight	221.20 g/mol
Synonyms	(6-(2,5-Difluorophenyl)pyridin-3-yl)methanol; 3-Pyridinemethanol, 6-(2,5-difluorophenyl)-; 6-(2,5-Difluorophenyl)-3-pyridinemethanol; 6-(2,5-Difluorophenyl)nicotinyl alcohol; 6-(2,5-Difluorophenyl)pyridine-3-methanol; 5-(Hydroxymethyl)-2-(2,5-difluorophenyl)pyridine
EINECS	Contact for details

Quality Control

Our [6-(2,5-Difluorophenyl)Pyridin-3-Yl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, it should be handled under a dry inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.