Description

5-(2,4-Difluorophenyl)Nicotinaldehyde is a high-purity, multi-functional chemical building block featuring a nicotinaldehyde core substituted with a difluorophenyl group. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the difluorophenyl and pyridine motifs contribute to biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs, due to its conjugated system.
• Chemical Biology Probes: Useful for constructing fluorescent tags or photoaffinity labels for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated aldehyde scaffold.

Basic Information

Product Name	5-(2,4-Difluorophenyl)Nicotinaldehyde
CAS No.	887973-79-7
Molecular Formula	C12H7F2NO
Molecular Weight	219.19 g/mol
Synonyms	5-(2,4-Difluorophenyl)pyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 5-(2,4-difluorophenyl)-; Nicotinaldehyde, 5-(2,4-difluorophenyl)-; 5-(2,4-Difluorophenyl)-3-pyridylcarboxaldehyde; 5-(2,4-Difluorophenyl)-3-formylpyridine; 2,4-Difluoro-5-(3-pyridinyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 5-(2,4-Difluorophenyl)Nicotinaldehyde is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.