Description

6,7-Difluoro-3,4-Dihydro-2H-Quinoxaline-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a difluoro-substituted quinoxaline core. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting challenging disease areas. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in developing novel therapeutics, where its specific fluorination pattern and protected carboxylic acid group enable precise molecular construction.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those containing the quinoxaline pharmacophore.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluoroquinoxaline structure can contribute to biological activity and metabolic stability.
• Material Science: Acts as a monomer or functional additive in the research of specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a molecular probe or a tagged scaffold for studying biological interactions and enzyme mechanisms.
• Organic Synthesis: Utilized by synthetic chemists as a versatile building block for constructing complex heterocyclic compounds in academic and industrial R&D.

Basic Information

Product Name	6,7-Difluoro-3,4-Dihydro-2H-Quinoxaline-1-Carboxylic Acid tert-Butyl Ester
CAS No.	887590-33-2
Molecular Formula	C₁₃H₁₄F₂N₂O₂
Molecular Weight	268.26 g/mol
Synonyms	tert-Butyl 6,7-difluoro-3,4-dihydro-2H-quinoxaline-1-carboxylate; 6,7-Difluoro-1,2,3,4-tetrahydroquinoxaline-1-carboxylic acid tert-butyl ester; 2H-Quinoxaline-1-carboxylic acid, 6,7-difluoro-3,4-dihydro-, 1,1-dimethylethyl ester; 887590-33-2; 6,7-Difluoro-1,2,3,4-tetrahydroquinoxaline-1-tert-butyl carboxylate; 1-Boc-6,7-difluoro-1,2,3,4-tetrahydroquinoxaline
EINECS	Contact for details

Quality Control

Our 6,7-Difluoro-3,4-Dihydro-2H-Quinoxaline-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.