Description

5-Bromo-2-(trifluoromethoxy)toluene is a high-value halogenated aromatic building block characterized by its bromine and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Active Ingredient Development: Used in research to create novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced lipophilicity and bioactivity.
• Ligand and Catalyst Synthesis: Serves as a precursor for sophisticated ligands in catalysis and as a building block for functionalized materials in organic electronics.
• Chemical Research & Development: Employed in academic and industrial labs for method development, exploring new cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), and creating compound libraries for screening.
• Fluorine Chemistry Studies: A valuable substrate for investigating the influence of the trifluoromethoxy group on chemical reactivity and physical properties in aromatic systems.

Basic Information

Product Name	5-Bromo-2-(trifluoromethoxy)toluene
CAS No.	887268-26-0
Molecular Formula	C9H6BrF3O
Molecular Weight	267.04 g/mol
Synonyms	1-Bromo-4-methyl-2-(trifluoromethoxy)benzene; 2-Bromo-5-methylanisole, α,α,α-trifluoro-; Benzene, 1-bromo-4-methyl-2-(trifluoromethoxy)-; 5-Bromo-2-(trifluoromethoxy)-1-methylbenzene; 4-Methyl-2-(trifluoromethoxy)bromobenzene; 2-(Trifluoromethoxy)-5-bromotoluene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethoxy)toluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment ensures the material meets the high standards required for sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.