Description

1H-Indole-3-Sulfonyl Chloride is a versatile and highly reactive chemical building block, primarily used as a key intermediate in advanced organic synthesis. Its core value proposition lies in its ability to act as a sulfonylation reagent, facilitating the introduction of the sulfonyl group into target molecules, which is critical for modulating biological activity and physical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active pharmaceutical ingredients (APIs), drug candidates, and specialty fine chemicals. Its precise reactivity makes it indispensable for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the indole-sulfonyl moiety confers specific activity.
• Peptide Modification & Bioconjugation: Employed to selectively modify amino acid side chains (e.g., lysine) in peptides and proteins for research, diagnostics, and therapeutic applications.
• Material Science Research: Serves as a monomer or precursor for developing functional polymers, dyes, and organic electronic materials with tailored properties.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and affinity labels to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1H-Indole-3-Sulfonyl Chloride
CAS No.	886578-15-0
Molecular Formula	C8H6ClNO2S
Molecular Weight	215.66 g/mol
Synonyms	Indole-3-sulfonyl chloride; 3-Indolesulfonyl chloride; 1H-Indole-3-sulfonyl chloride; 3-Sulfonylchloride indole; Indol-3-ylsulfonyl chloride; 1H-Indol-3-sulfonyl chloride; 886578-15-0; 3-Indolylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity determination, to meet exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.