Description

1-(Difluoromethyl)-2,4,5-Trifluorobenzene is a highly fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group and multiple fluorine atoms, makes it a critical intermediate for introducing fluorine motifs into target molecules, which is a key strategy in modern pharmaceutical and agrochemical design. This compound is primarily sought by R&D chemists and process development scientists in the life sciences sector for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorination improves compound efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays (LCDs) and dielectric materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, fluorinated molecular architectures.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for incorporating fluorine-18, a common radioisotope used in medical imaging.

Basic Information

Product Name	1-(Difluoromethyl)-2,4,5-Trifluorobenzene
CAS No.	886510-29-8
Molecular Formula	C7H3F5
Molecular Weight	182.09 g/mol
Synonyms	2,4,5-Trifluoro-1-(difluoromethyl)benzene; α,α-Difluoro-2,4,5-trifluorotoluene; 2,4,5-Trifluorobenzylidene Difluoride; (Difluoromethyl)-2,4,5-trifluorobenzene; 1-(Difluoromethyl)-2,4,5-trifluorobenzene; 886510-29-8
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-2,4,5-Trifluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in cGMP and ISO-compliant environments, ensuring reliable supply for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reactive metals. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.